AI-Supported Psycho-Oncology Care for Breast Cancer: A Case Report on Digital Biomarkers and Post-Mastectomy Distress
- Authors
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Meriem Lameri
Department of Serology and Cell Therapy, National Blood Transfusion Center, Tunisia
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Yosr Trabelsi
Department of Pharmacy, National Marrow Bone Transplant Center, Tunisia
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Tarek Kamergi
Department of Pharmacy, National Marrow Bone Transplant Center, Tunisia
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Linda Bouallegue
Department of Pharmacy, National Marrow Bone Transplant Center, Tunisia
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- Keywords:
- Artificial Intelligence, Breast Cancer, Digital Biomarkers, Mastectomy, Psycho-Oncology
- Abstract
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Psychosocial distress has been demonstrated to have a significant impact on the quality of life and treatment adherence of patients diagnosed with breast cancer. The integration of digital biomarkers with artificial intelligence (AI) has emerged as a novel approach for the timely detection and management of distress. This case report describes a 42-year-old female breast cancer patient who experienced severe psychosocial distress following the commencement of chemotherapy and subsequent mastectomy. The utilisation of artificial intelligence (AI)-driven digital biomarkers, derived from smartphone applications, in conjunction with the analysis of digital communications and virtual conversational assistance (e.g. ChatGPT), enabled clinicians to expeditiously identify early indications of distress and promptly implement bespoke psychosocial interventions. The early identification of psychological distress in patients receiving cancer treatment has been demonstrated to result in significant improvements in their psychological health, treatment adherence, and overall quality of life. This underscores the potential of artificial intelligence-supported psycho-oncology interventions. The study observed improvements in the following areas: increased regularity of sleep, increased physical activity levels, and normalised heart-rate variability patterns, as detected via Google Fit. These improvements were accompanied by reduced anxiety and improved emotional stability during the follow-up period.
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- Published
- 2026-06-02
- Data Availability Statement
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The data that supports the findings of this study are available from the corresponding author upon reasonable request.
- Section
- Case Report
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Copyright (c) 2026 Meriem Lameri, Yosr Trabelsi, Tarek Kamergi, Leila Achour, Linda Bouallegue, Chema Drira, Ikram Fazaa

This work is licensed under a Creative Commons Attribution 4.0 International License.
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