Cancer Chemoprevention: An Exploration of the Efficacy and Potential of Various Materials (Synthetic and Natural)

Ikram Fazaa

Centre National de greffe de moelle osseuse de Tunis

Leila Achour

Departement of pharmacy, Marrow bone transplant center Tunisia

Yosr Trabelsi

Departement of pharmacy, Marrow bone transplant center Tunisia

Hajer Felfel

University of monastir, Faculty of pharmacy of Monastir, Tunisia

Freddy Mounsef

Departement of pharmacy, Hospital of Saint-Etienne

Chema Drira

Departement of pharmacy, Marrow bone transplant center Tunisia

DOI: https://doi.org/10.61706/MECOJ160139

Keywords: cancer chemoprevention, Natural Compounds, Synthetic Compounds

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Abstract

The increasing incidence of cancer around the world has led to a growing focus on cancer chemoprevention in contemporary medical research. Chemoprevention, defined as the use of natural or synthetic bioactive substances to impede, delay, or mitigate tumor growth, is a critical component of cancer research and treatment. In light of the limitations of current chemotherapy, including toxicity and chemoresistance, which result in suboptimal success rates, the pursuit of safer and more effective alternatives has become imperative. The present study explores the efficacy of various natural and synthetic compounds as chemopreventive agents, drawing upon evidence from pre-clinical trials. This paper investigated the actions of chemopreventive drugs in obstructing cancer progression, with a specific emphasis on their role in safeguarding DNA integrity and suppressing the growth of premalignant cells. A comprehensive evaluation of pre-clinical trials was conducted to assess the practicality and advantages of using dietary components as chemopreventive agents.The trials reviewed provide substantial evidence supporting the potential of dietary components in cancer chemoprevention. These elements have demonstrated encouraging efficacy in impeding cancer progression by targeting DNA protection and constraining the proliferation of premalignant cells. Moreover, the implementation of these chemopreventive approaches in clinical trials has exhibited considerable promise, particularly in the protection of individuals at high risk of cancer development. The demonstrated efficacy of chemopreventive agents in diminishing cancer risk, especially in populations with heightened vulnerability, significantly reinforces their validity and potential utility. In light of the challenges associated with conventional chemotherapy, there is a growing recognition of the potential for a paradigm shift towards the integration of multiple chemopreventive compounds. This integration could represent a transformative phase in cancer treatment strategies.

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