Radical Resection and Deltopectoral Flap Reconstruction Solving the Dilemma of Repeatedly Recurring Submandibular Pleomorphic Adenoma: A Case Report

Authors
Keywords:
Pleomorphic Adenoma, Salivary Gland Tumors, Salivary Neoplasms, Recurrent Pleomorphic Adenoma, Deltopectoral Flap
Abstract

Pleomorphic adenoma is regarded as the most prevalent salivary gland neoplasm, constituting approximately 80% of all salivary gland tumors. Incomplete surgical resection and/or tumor pseudopodia have been identified as risk factors for recurrence, which can occur despite adequate surgical intervention. The surgical management of recurrence remains challenging, with the complexity of the procedure increasing with subsequent recurrences. With each recurrence, surgical management becomes more challenging. While a considerable number of cases of recurrent parotid pleomorphic adenoma have been documented in the literature, reports of recurrent submandibular gland pleomorphic adenoma are comparatively rare. A 71-year-old female patient with a history of pleomorphic adenoma of the submandibular gland with a seventh recurrence of the malignancy. This recurrence posed significant challenges to the surgical team during the resection process. The patient exhibited 30 years of recurrent symptoms following left submandibular sialadenectomy, with subsequent surgical interventions for management. The surgical intervention involved radical resection, followed by reconstruction of the defect using a tunneled de-epithelialized deltopectoral flap. The patient exhibited a seamless postoperative recovery trajectory, with discharge occurring three days after the procedure. Two years post-surgery, the patient exhibited no evidence of local recurrence. It is hypothesized that radical resection, in conjunction with reconstruction, should be considered a valid surgical intervention to address the surgical dilemma in these cases.

References

Abdallah, A., Hamdy, O., Metwally, I. H., Setit, A., & Awny, S. (2025). Recurrent pleomorphic adenoma: Epidemiology and surgical challenges; a single tertiary center experience. Journal of Stomatology Oral and Maxillofacial Surgery, 126(3), 102164. https://doi.org/10.1016/j.jormas.2024.102164

Aro, K., Valle, J., Tarkkanen, J., Mäkitie, A., & Atula, T. (2019). Repeatedly recurring pleomorphic adenoma: a therapeutic challenge. Acta Otorhinolaryngologica Italica, 39(3), 156–161. https://doi.org/10.14639/0392-100X-2307

Chan, R. C. L., & Chan, J. Y. W. (2014). Deltopectoral Flap in the Era of Microsurgery. Surgery Research and Practice, 2014, 1–5. https://doi.org/10.1155/2014/420892

Chauhan, I., & Garg, K. (2023). Recurrent pleomorphic adenoma of submandibular gland — a rare entity. The Egyptian Journal of Otolaryngology, 39(1), 123. https://doi.org/10.1186/s43163-023-00489-x

Dai, L., Lou, W., Fang, Q., & Zhang, X. (2020). Recurrent Pleomorphic Adenoma of the Parotid Gland: Experience of 128 Patients with First Recurrence. Journal of Oncology, 2020, 1–5. https://doi.org/10.1155/2020/6645340

Dulguerov, P., Todic, J., Pusztaszeri, M., & Alotaibi, N. H. (2017). Why Do Parotid Pleomorphic Adenomas Recur? A Systematic Review of Pathological and Surgical Variables. Frontiers in Surgery, 4. https://doi.org/10.3389/fsurg.2017.00026

Ghaloo, S. K., Qayyum, M. U., Shaikh, O. S., Faisal, M., Keerio, A. A., & Hussain, R. T. (2022). Carcinoma ex-pleomorphic adenoma of mandible: A case report and review of literature. International Journal of Surgery Case Reports, 100, 107729. https://doi.org/10.1016/j.ijscr.2022.107729

Inan, S., Aydin, E., Turkoglu Babakurban, S., & Yilmaz Akcay, E. (2016). Recurrent Pleomorphic Adenoma of the Submandibular Gland. Turk Otolarengoloji Arsivi/Turkish Archives of Otolaryngology, 54(1), 43–46. https://doi.org/10.5152/tao.2016.1281

Li, Z., Yuan, G., Zhang, Y., Huang, J., Xu, F., Xiong, Y., & Zeng, X. (2025). Recurrence of Pleomorphic Adenoma in the Submandibular Gland: A Case Report and Literature Review. Current Medical Imaging Formerly Current Medical Imaging Reviews, 21. https://doi.org/10.2174/0115734056333595250226071534

Mariano, F. V., Giovanetti, K., Saccomani, L. F. V., Del Negro, A., Kowalski, L. P., Krepischi, A. C. V., & Altemani, A. (2016). Carcinoma ex-pleomorphic adenoma derived from recurrent pleomorphic adenoma shows important difference by array CGH compared to recurrent pleomorphic adenoma without malignant transformation. Brazilian Journal of Otorhinolaryngology, 82(6), 687–694. https://doi.org/10.1016/j.bjorl.2015.12.004

Mikami, T., Kagimoto, S., Yabuki, Y., Yasumura, K., Iwai, T., Maegawa, J., Suganuma, N., Hirakawa, S., & Masudo, K. (2017). Deltopectoral flap revisited for reconstruction surgery in patients with advanced thyroid cancer: a case report. BMC Surgery, 17(1), 101. https://doi.org/10.1186/s12893-017-0297-8

Nicholas, S. E., Fu, W., Liang, A. L., DeLuna, R., Vujaskovic, L., Bishop, J., Page, B. R., Quon, H., Gourin, C., Fakhry, C., Eisele, D., & Kiess, A. P. (2021). Radiation Therapy After Surgical Resection Improves Outcomes for Patients With Recurrent Pleomorphic Adenoma. Advances in Radiation Oncology, 6(3), 100674. https://doi.org/10.1016/j.adro.2021.100674

Nouraei, S. A. R., Ferguson, M. S., Clarke, P. M., Sandison, A., Sandhu, G. S., Michaels, L., & Rhys-Evans, P. (2006). Metastasizing Pleomorphic Salivary Adenoma. Archives of Otolaryngology–Head & Neck Surgery, 132(7), 788. https://doi.org/10.1001/archotol.132.7.788

Sedat, A., Demir, M. G., Akbulut, S., Altıntoprak, N., & Basak, K. (2015). Recurrent Pleomorphic Adenoma of Submandibular Region. SAJ Case Reports. https://doi.org/10.18875/2375-7043.1.302

Steele, N. P., Wenig, B. M., & Sessions, R. B. (2007). A case of pleomorphic adenoma of the parotid gland metastasizing to a mediastinal lymph node. American Journal of Otolaryngology, 28(2), 130–133. https://doi.org/10.1016/j.amjoto.2006.07.002

Valstar, M. H., de Ridder, M., van den Broek, E. C., Stuiver, M. M., van Dijk, B. A. C., van Velthuysen, M. L. F., Balm, A. J. M., & Smeele, L. E. (2017). Salivary gland pleomorphic adenoma in the Netherlands: A nationwide observational study of primary tumor incidence, malignant transformation, recurrence, and risk factors for recurrence. Oral Oncology, 66, 93–99. https://doi.org/10.1016/j.oraloncology.2017.01.004

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2026-01-24
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Case Report
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Copyright (c) 2026 Shadi Awny, Sameh Roshdy, Amany Hassan, Doaa Khedr, Ahmed A Ghanem, Abdullah N Nassar, Mohammad Zuhdy

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How to Cite

Awny, S., Roshdy, S., Hassan, A., Khedr, D., Ghanem, A. A., Nassar, A. N., & Zuhdy, M. (2026). Radical Resection and Deltopectoral Flap Reconstruction Solving the Dilemma of Repeatedly Recurring Submandibular Pleomorphic Adenoma: A Case Report. Middle Eastern Cancer and Oncology Journal, 2(1), 26-32. https://doi.org/10.61706/MECOJ160204

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